Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium

We show that the developing PE is influenced by Notch signaling derived from the endothelium

Laura Andrés‐Delgado; María Galardi‐Castilla; Juliane Münch; Marina Peralta; Alexander Ernst; Juan Manuel González‐Rosa; Federico Tessadori; Luis Santamaría; Jeroen Bakkers; Julien Vermot; José Luis Pompa; Nadia Mercader

2020

Scholarcy highlights

  • The epicardium is the outer mesothelial layer of the heart
  • We show that the developing PE is influenced by Notch signaling derived from the endothelium
  • The epicardium is the mesothelial layer of the heart that covers the myocardium
  • The embryonic epicardium acts as a source of epicardial-derived cells, that can differentiate into other cell types such as adipocytes, vascular smooth muscle cells and cardiac fibroblasts
  • Whereas activation of the Notch pathway in wt1b+ cells did not affect PE formation, we found that overexpression of NICD in endothelial cells resulted in a significant increase in PE cell numbers
  • The following day sections where washed twice with posthybridization buffer 1 for 30 min at 65°C and twice with posthybridization buffer 2
  • The PE forms a bridge to the myocardium and PE cells are transferred in this way to the myocardial surface
  • They contribute to cardiac fibrosis, control the inflammatory response and promote neoangiogenesis and proliferation of cardiomyocytes

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