Cyclodextrin complexes: Perspective from drug delivery and formulation

Cyclodextrins have been widely investigated as a unique pharmaceutical excipient for past few decades and is still explored for new applications

Shery Jacob

2018

Scholarcy highlights

  • Cyclodextrins have been widely investigated as a unique pharmaceutical excipient for past few decades and is still explored for new applications
  • Factors affecting complexation, techniques to enhance complexation efficiency, the preparation methods for molecular inclusion complexes and release of guest molecules are discussed in brief
  • The potential of CDs by means of inclusion complex formation have widen the applicability of these materials in various drug delivery systems including ocular, osmotic, mucoadhesive, transdermal, nasal, and targeted delivery systems
  • Feasibility studies have been performed on the benefit of these cyclic oligomers as nanocarriers, a strategy that can modify the drugs with improved physicochemical properties
  • Studies demonstrated the feasibility of CDs to self-assemble in the form of stable nanoaggregates, which may extend the scope of CDs in drug delivery to the continually expanding list of new drug entities

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