GENDER AS PREDICTOR AND MODERATOR OF OUTCOME IN COGNITIVE BEHAVIOR THERAPY AND PHARMACOTHERAPY FOR ADULT DEPRESSION: AN “INDIVIDUAL PATIENT DATA” META-ANALYSIS

We examined the extent to which gender moderates or predicts outcome, using the Hamilton Rating Scale for Depression-17-item, with mixed effects models

Pim Cuijpers; Erica Weitz; Jos Twisk; Christine Kuehner; Ioana Cristea; Daniel David; Robert J. DeRubeis; Sona Dimidjian; Boadie W. Dunlop; Mahbobeh Faramarzi; Ulrich Hegerl; Robin B. Jarrett; Sidney H. Kennedy; Farzan Kheirkhah; Roland Mergl; Jeanne Miranda; David C. Mohr; Zindel V. Segal; Juned Siddique; Anne D. Simons; Jeffrey R. Vittengl; Steven D. Hollon

2014

Scholarcy highlights

  • It has yet to be established whether gender moderates or predicts outcome of psychological and pharmacological treatments for adult depression because: individual randomized trials typically lack sufficient statistical power to detect moderators and predictors and meta-analyses cannot examine such associations directly
  • We examined the extent to which gender moderates or predicts outcome, using the Hamilton Rating Scale for Depression-17-item, with mixed effects models
  • The lack of predictive relations in a this good sized sample suggests that gender does not moderate differential response to cognitive behavior therapy versus medication treatment and that it neither predicts nonspecific response across the treatments nor the specificity of response for either treatment with respect to pill placebo

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