Studies on digitalis; X. Digitoxin metabolites in human myocardium and relationship between myocardial and serum concentrations of digitoxin in patients on maintenance treatment

The levels of digitoxin and cardioactive metabolites were measured in 42 atrial biopsies with a 86Rb method mod(fiedfor analysis of myocardial sampies

Liv Storstein

2016

Scholarcy highlights

  • The levels of digitoxin and cardioactive metabolites were measured in 42 atrial biopsies with a 86Rb method mod(fiedfor analysis of myocardial sampies
  • Myocardial and serum concentrations were compared in 23 patients; there was no significant correlation
  • Calculated from the free drug concentrations, the mean myocardial serum ratio was 200, which reflects the high affinity of digitoxin and cardioactive metabolites to the myocardium
  • The myocardium contained less unchanged digitoxin and more hydrolyzed and conjugated metabolites than serum
  • Hydroxylated metabolites in myocardium were not significantly changed compared to serum

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