Metabolism and excretion of digitoxin in man

These results demonstrate the limited degradation of dgt in man and suggest that the pharmacologic effects are mediated by dgt itself

H. F. Vöhringer

2016

Scholarcy highlights

  • The levels of digitoxin and its metabolites in the plasma, urine, and feces of 6 subjects given a single oral dose of 1 mg 3H-dgt have been determined using CHCl3-extraction and thin-layer chromatography
  • The peak plasma level of 4.1% of the given dose per 1 plasma occurred at 40 min after drug administration and was followed by an exponential decline with a mean half-life of 6.8 days
  • Within 192 hr, 22% of the given dose has been excreted in urine and 13% in feces
  • Dgt accounted for 60% of the eliminated amount within the experimental time
  • Since dgt-mono and the more polar compounds have shown an inverse relationship during the study, a bacterial cleavage following a conjugation of dgt-mono and an enterohepatic circulation of its lipophilic nwiety are suggested
  • These results demonstrate the limited degradation of dgt in man and suggest that the pharmacologic effects are mediated by dgt itself

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