Interaction of warfarin and nonsystemic gastrointestinal drugs

The absorption and pharmacologic action of warfarin may be influenced by such factors as gut motility, pH, solubility, and chemical binding

Donald S. Robinson; David M. Benjamin; John J. McCormack

2016

Scholarcy highlights

  • The absorption and pharmacologic action of warfarin may be influenced by such factors as gut motility, pH, solubility, and chemical binding
  • To investigate the possible interaction of warfarin with nonsystemic gastrointestinal drugs in clinical use, cholestyramine, an antacid mixture containing magnesium and aluminum hydroxide, and psyllium hydrophyllic mucilloid were studied in 6 normal subjects
  • In vitro experiments demonstrated significant binding of warfarin to cholestyramine at a pH above its pKa of 5.5

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