The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responses in man

The findings suggest increased metabolic inactivation of warfarin by induction of liver microsomal enzymes

Murdo G. MacDonald; Donald S. Robinson; David Sylwester; Julian J. Jaffe

2016

Scholarcy highlights

  • Ten male volunteers received phenobarbital, glutethimide, chloral betaine, and a placebo at bedtime for 3 week periods
  • Plasma warfarin levels and prothrombin times were determined after a single oral dose of warfarin prior to and immediately following placebo or hypnotic drug treatment
  • Phenobarbital and glutethimide interfered with the hypoprothrombinemic effect of warfarin; chloral betaine and placebo did not
  • The findings suggest increased metabolic inactivation of warfarin by induction of liver microsomal enzymes

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