Brachial artery ultrasound: A noninvasive tool in the assessment of triglyceride-rich lipoproteins

We discovered that solution suppressedthe freefatty acids solow that it changedthe respiratory quotient at the myocardium

Robert A. Vogel

2009

Scholarcy highlights

  • Endothelial function has been used as a surrogateor intermediatebiologicalmarkerforcoronary atherosclerosisand cardiovascularevents.Traditionally,atherosclerosis has been viewed as a disease of low-density lipoproteindepositionin subintimalspaces.Through a sequence of events, there is eventual plaque formation and rupture leadingtothrombosisand,to a cardiovascular event.This process falls short,in the understanding of why so many different risk factors interact in a multiplica
  • Endothelial dysfunction can be used as biological markers to identify the lipoproteinswhich are predominantlyatherogenic.Lipoproteinswhichhave been identified as depressing endothelial function include LDL, oxidized LDL, lipoprotein(a), small dense LDL, postprandial chylomicron remnants, very low-density lipoprotein remnants, free fatty acids,and low levelsof high-densitylipoprotein(HDL)
  • Endothelial dysfunction may be associated with increased nitric oxide destruction or impaired synthesis as occurs with hypercholesterolemiaor hypertriglyceridemia.Experimental atherosclerosis is associated with increased superoxide productionand increasednitricoxideproduction.Superoxidedeactivatesnitric oxide more rapidly than does superoxide dismutase
  • Rackley: Endothelialinteraction offersthe opportunity to bring the metabolic aspects of cardiovasculardisease intothe hemodynamicaspect.One major challengeis how to explain some of the acute events based on chronic metabolic and physiologicabnormalities.About a yearago,the Indianapolis group showed that the infusion of free fatty acids, first in diabetics and in normal, lean, nondiabetic individuals, inducesthe same vasoconstrictionrate as observedwith various lipid components.The sourceof freefatty acidsishiglyceride
  • After a cigarette is smoked, free fatty acids and circulating catecholamines increase.Anotherway to raise freefatty acidsis to give a heparin dose.On the other hand, a way to lowerfreefattyacids is by using nicotinic acid. we have the opportunityto look at someexcitingmetabolicinterventionsthat may tie in some of these chroniclipid and metabolic disturbanceswith acute events.Theseinterventionsmay call intothe forefronttriglycerides and free fatty acids
  • Data suggest that endothelial dysfunction is a predictor of future cardiovascular events

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