Plaque Characteristics of the Coronary Segment Proximal to the Culprit Lesion in Stable and Unstable Patients

The present study showed that VH-IVUS-derived thin-cap fibroatheroma plaque in nonculprit lesions were more frequent in acute coronary syndrome patients than those in stable angina patients

Tomohiro Nakamura; Norifumi Kubo; Hiroshi Funayama; Yoshitaka Sugawara; Junya Ako; Shin-ichi Momomura


Scholarcy highlights

  • Virtual histology intravascular ultrasound using spectral analysis of the radiofrequency ultrasound backscatter signals was introduced to clinical practice to characterize plaque composition. The purpose of this study was to examine the relationship between the plaque composition of nonculprit segments assessed by virtual histology intravascular ultrasound and clinical presentation
  • Each quantitative value of greyscale IVUS was not different between the 2 groups, acute coronary syndrome patients showed significantly higher ratio of dense calcium and necrotic core plaque compared with stable angina patients
  • VH-IVUS-derived thin-cap fibroatheroma) was more frequently observed in ACS patients, and the presence of VH-TCFA was related to an increased level of plasma high sensitivity C-reactive protein
  • The present study showed that VH-TCFA plaque in nonculprit lesions were more frequent in ACS patients than those in SA patients
  • The present study using VH-IVUS analysis had revealed that plaque characteristics of nonculprit segments were related to clinical presentation
  • ACS patients had higher prevalence of vulnerable plaque. These results have suggested that VH-IVUS has clinical implication for identifying vulnerable patients as well as vulnerable plaques
  • Further studies are needed to evaluate the impact of VH-IVUS-derived thin-cap fibroatheroma on future clinical events

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