Strategy for Tuning the Photophysical Properties of Photosensitizers for Use in Photodynamic Therapy

A novel approach for tuning spectral properties, as well as minimizing aggregation, in zinc porphyrin and zinc phthalocyanine-based compounds is presented

Noureen Siraj; Paulina E. Kolic; Bishnu P. Regmi; Isiah M. Warner

2015

Scholarcy highlights

  • A novel approach for tuning spectral properties, as well as minimizing aggregation, in zinc porphyrin and zinc phthalocyanine-based compounds is presented
  • Phthalocyanine dyes are converted into GUMBOS by replacing sodium cations with bulky hydrophobic cations
  • A very simple cation-exchange reaction minimizes aggregation of the dyes, which subsequently improves molar absorptivity at higher wavelengths. This is highly beneficial for photodynamic therapy since it allows these compounds to be irradiated at longer wavelengths and produce singlet oxygen efficiently
  • Particular emphasis is placed on use of these compounds as photosensitizers in photodynamic therapy
  • A bulky hydrophobic cation, trihexyltetradecylphosphonium, is paired with anionic porphyrin and phthalocyanine dyes to produce a group of uniform materials based on organic salts that absorb at longer wavelengths with high molar absorptivity and high photostability
  • Nanoparticles derived from these GUMBOS possess positively charged surfaces with high zeta potential values, which are highly desirable for PDT
  • Upon irradiation at longer wavelengths, these GUMBOS produced singlet oxygen with greater efficiency as compared to the respective parent dyes

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