A Bioorthogonal Approach for the Preparation of a Titanium-Binding Insulin-like Growth-Factor-1 Derivative by Using Tyrosinase

The generation of metal surfaces with biological properties, such as cell‐growth‐enhancing and differentiation‐inducing abilities, could be potentially exciting for the development of functional materials for use in humans, including artificial dental implants and joint replacements

Chen Zhang

2016

Scholarcy highlights

  • The generation of metal surfaces with biological properties, such as cell‐growth‐enhancing and differentiation‐inducing abilities, could be potentially exciting for the development of functional materials for use in humans, including artificial dental implants and joint replacements
  • We have used a mussel‐inspired bioorthogonal approach to design a 3,4‐hydroxyphenalyalanine‐containing recombinant insulin‐like growth‐factor‐1 using a combination of recombinant DNA technology and tyrosinase treatment for the surface modification of titanium
  • The modified growth factor prepared in this study exhibited strong binding affinity to titanium, and significantly enhanced the growth of NIH3T3 cells on the surface of titanium
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