Phosphoramidites: Privileged Ligands in Asymmetric Catalysis

A particular advantage is their modular synthesis, which allows fine-tuning for a specific catalytic reaction

Johannes F. Teichert; Ben L. Feringa

2010

Scholarcy highlights

  • A meteoric rise: After their first application in asymmetric conjugate addition reactions in 1996, phosphoramidites have developed into one of the most effective ligands in enantioselective transition-metal catalysis
  • A particular advantage is their modular synthesis, which allows fine-tuning for a specific catalytic reaction
  • Asymmetric catalysis with transition-metal complexes is the basis for a vast array of stereoselective transformations and has changed the face of modern synthetic chemistry
  • Key to this success has been the design of chiral ligands to control the regio, diastereo, and enantioselectivity
  • Phosphoramidites have emerged as a highly versatile and readily accessible class of chiral ligands. Their modular structure enables the formation of ligand libraries and easy fine-tuning for a specific catalytic reaction
  • In this Review, recent developments in asymmetric catalysis with phosphoramidites used as ligands are discussed, with a focus on the formation of carbon–carbon and carbon–heteroatom bonds

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