Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery

Controlled delivery of protein therapeutics remains a challenge

Dan Shao

2018

Scholarcy highlights

  • Controlled delivery of protein therapeutics remains a challenge
  • After surface cloaking with cancer‐cell‐derived membrane fragments, these bioinspired RNase A‐loaded mesoporous silica nanoparticles exhibit homologous targeting and immune‐invasion characteristics inherited from the source cancer cells
  • The efficient in vitro and in vivo anti‐cancer performance, which includes increased blood circulation time and enhanced tumor accumulation along with low toxicity, suggests that these cell‐membrane‐coated, dual‐responsive degradable MSNs represent a promising platform for the delivery of bio‐macromolecules such as protein and nucleic acid therapeutics
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