Morphological and electrophysiological study of distal motor nerve fiber degeneration and sprouting after irreversible cholinesterase inhibition

The present study demonstrates a direct cytotoxic effect of sarin and indicates that this organophosphate agent may be an important neurotoxicological tool to understand the mechanisms involved in nerve sprouting

Masaru Kawabuchi; Wagner M. Cintra; Sharad S. Deshpande; Edson X. Albuquerque

2004

Scholarcy highlights

  • A single subcutaneous injection of a sublelthal dose of the irreversible organophosphate sarin in rat induced a non-Wallerian-type axonal degeneratin of the neuromuscular synapse in the slow twitch, soleus muscle
  • The non-Wallerian-type axonal degeneration of the neuromuscular synapse was characterized by bead or balloon-like varicosities of the focal, dista, and terminal nerve fibers and a retraction of terminal axons
  • Transients similar to miniature endplate potentials were recorded along the muscle fiber at distances of 800–2500 μm away from the parent endplate
  • The present study demonstrates a direct cytotoxic effect of sarin and indicates that this organophosphate agent may be an important neurotoxicological tool to understand the mechanisms involved in nerve sprouting

Need more features? Save interactive summary cards to your Scholarcy Library.