Amphiphilic Cholic-Acid-Modified Dextran Sulfate and its Application for the Controlled Delivery of Superoxide Dismutase

This study demonstrates that the amphiphilic DS‐CA provides a promising strategy for oral delivery of protein/peptide drugs

Yubing Xiong

2012

Scholarcy highlights

  • A novel amphiphilic and biodegradable polyelectrolyte DS‐CA is prepared by the esterification of DS with CA
  • DS‐CA can self‐assemble into stable nanoparticles in water
  • SOD can effectively associate with DS‐CA at pH = 5.0 by virtue of electrostatic and hydrophobic interactions
  • Increasing the CA substitution degree of DS‐CA can significantly enhance the cellular uptake of the loaded SOD
  • This study demonstrates that the amphiphilic DS‐CA provides a promising strategy for oral delivery of protein/peptide drugs
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