Motoneuron survival is not affected by the proximo-distal level of axotomy but by the possibility of regenerating axons to gain access to the distal nerve stump

We examined hypoglossal neuron survival twelve months after a proximal nerve transection with prevented regeneration

E. Tõrnqvist


Scholarcy highlights

  • The hypoglossal nerve of adult rats was transected either proximally in the neck or close to the tongue
  • The aim of this study was to examine whether axotomy‐induced motoneuron death in adult mammals differ: with the distance between the site of injury and the nerve cell body, and if contact between the transected nerve stumps is established after the injury, compared with cases where contact is prevented
  • Our results show that there was no significant difference in neuronal survival after a proximal nerve transection compared with a distal one, neither if contact between the nerve stumps was established nor if it was prevented
  • Contact between the transected nerve stumps increased the likelihood of neuronal survival significantly after both proximally and distally located injury compared to nerve injury with prevented regeneration
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