SSRIs and cognitive performance in a working sample

Studies of the impact of antidepressant use on cognitive performance have frequently been carried out among the elderly or on healthy volunteers

Emma J. K. Wadsworth

2005

Scholarcy highlights

  • Studies of the impact of antidepressant use on cognitive performance have frequently been carried out among the elderly or on healthy volunteers
  • SSRI users and controls completed a battery of laboratory based computer tasks measuring mood and cognitive function pre- and post-work at the start and end of a working week
  • SSRI use was associated with memory impairment: poorer episodic, though not working or semantic memory
  • Effects of SSRI use on recognition memory seemed to vary according to the underlying psychopathology, while effects on delayed recall were most pronounced among those whose symptoms had not resolved
  • There were no detrimental effects on psychomotor speed, attention, mood or perceived human error at work

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