Effects of ammonium perchlorate on the reproductive performance and thyroid follicle histology of zebrafish

Adult zebrafish were reared up to eight weeks in control water or in water containing ammonium perchlorate at measured perchlorate concentrations of 18 and 677 ppm

Reynaldo PatiƱo; Melody R. Wainscott; Emilia I. Cruz-Li; Saravanan Balakrishnan; Cynthia McMurry; Vicki S. Blazer; Todd A. Anderson

2010

Scholarcy highlights

  • Adult zebrafish were reared up to eight weeks in control water or in water containing ammonium perchlorate at measured perchlorate concentrations of 18 and 677 ppm
  • Groups of eight females were paired with four males on a weekly basis to assess AP effects on spawned egg volume, an index of reproductive performance
  • At 677 ppm, spawn volume was reduced within one week and became negligible after four weeks
  • Fish were collected at the end of the exposures for whole-body perchlorate content and thyroid histopathological analysis
  • Fish perchlorate levels were about one-hundredth of those of treatment water levels, indicating that waterborne perchlorate does not accumulate in whole fish
  • Further research is needed to determine if AP at lower environmentally relevant concentrations affects the thyroid follicles of zebrafish

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