Methylsulfone polycglorinated biphenyl and 2,2-bis(chlorophenyl)-1,1-dichloroethylene metabolites in beluga whale (Delphinapterus leucas) from the St. Lawrence river estuary and western Hudson bay, Canada

We demonstrated that sulfone formation and clearance is related to metabolic capacity, and polychlorinated biphenyl, DDE, and MeSO2-PCB and -DDE toxicokinetics differ for St. Lawrence River estuary and western Hudson Bay beluga

Robert J. Letcher; Ross J. Norstrom; Derek C.G. Muir; Courtney D. Sandau; Krystyna Koczanski; Robert Michaud; Sylvian De Guise; Pierre Béland

2010

Scholarcy highlights

  • Kowledge is limited regarding methylsulfone-polychlorinated biphenyl, and especially MeSO2–2,2-bis(chlorophenyl)-1,1-dichloroethylene, metabolites in cetacean species
  • We hypothesized that the ability of beluga whale to biotransform PCB and DDE compounds, and to form and degrade their MeSO2 PCB and -DDE metabolites, is related to the capacity for xenobiotic metabolism
  • Lawrence River estuary and western Hudson Bay, Canada, which are contrasted by the exposure to different levels of cytochrome P450 enzyme-inducing, chlorinated hydrocarbon contaminants
  • The congener patterns were dominated by trichloro- and tetrachloro-MeSO2-PCBs, and tetrachloro- and pentachloro-MeSO2-PCBs in WHB and St. Lawrence River estuary animals, respectively
  • We demonstrated that sulfone formation and clearance is related to metabolic capacity, and PCB, DDE, and MeSO2-PCB and -DDE toxicokinetics differ for STL and WHB beluga
  • The results of this study indicate that MeSO2-PCBs and -DDEs need to be included in the toxicologic risk assessment of PCB and DDT exposure in odontocetes, and perhaps for cetaceans in general

Need more features? Save interactive summary cards to your Scholarcy Library.