Hydrovinylation Reactions - Atom-Economic Transformations with Steadily Increasing Synthetic Potential

The reaction of two alkenes to form a single product in a transition-metal-catalysed 1,2-hydrovinylation reaction generates a new stereogenic centre

Gerhard Hilt

2012

Scholarcy highlights

  • The reaction of two alkenes to form a single product in a transition-metal-catalysed 1,2-hydrovinylation reaction generates a new stereogenic centre
  • Recent applications for the synthesis of complex products enlarge the scope of the hydrovinylation reactions considerably
  • The application of styrene derivatives, norbornenes and other alkenes in asymmetric catalysis with a variety of chiral ligands leads to α-chiral alkene products in an atom-economic transformation
  • The 1,4-hydrovinylation of terminal alkenes and 1,3-dienes can be controlled by the electronic nature of the alkene starting material for the selective formation of linear or branched 1,4-dienes
  • These adducts can be used for the synthesis of 1,3- as well as 1,4-dicarbonyl derivatives upon ozonolysis of suitable intermediates
  • As an extension of the 1,4-hydrovinylation reaction a cobalt-catalysed 1,4-hydrobutadienylation reaction is reported where two different 1,3-dienes react selectively for the formation of 1,3,6-trienes

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