Modification of tumor cells by a low dose of Newcastle Disease Virus.

The results indicate that in this system the effect of viral xenogenization is not due to recognition of additional xenoor neoantigens

Paul Von Hoegen

2007

Scholarcy highlights

  • It was found that the frequency of cytotoxic T lymphocytes specific for the ESb tumor‐associated transplantation antigen and the cytotoxic anti‐tumor activity in bulk cultures of immune spleen cells were significantly increased when using virus‐modified tumor cells
  • For the stimulation of tumor‐specific cytolytic T lymphocytes the ESb tumor cells which are highly metastatic were infected with an avirulent strain of the paramyxovirus Newcastle Disease Virus
  • Infection of ESb cells with low amounts of NDV was sufficient to lead to an increase in cytolytic activity of tumor‐specific CTL after sensitization in vivo and restimulation in vitro
  • In split‐type experiments it could be shown at the clonal level that viral modification did not alter the specificity of ESb‐specific CTL
  • NDV modification instead led to a selective augmentation of the TATA‐specific CTL response
  • If the address matches an existing account you will receive an email with instructions to retrieve your username

Need more features? Save interactive summary cards to your Scholarcy Library.