The results indicate that in this system the effect of viral xenogenization is not due to recognition of additional xenoor neoantigens
2007
Key concepts
Scholarcy highlights
- It was found that the frequency of cytotoxic T lymphocytes specific for the ESb tumor‐associated transplantation antigen and the cytotoxic anti‐tumor activity in bulk cultures of immune spleen cells were significantly increased when using virus‐modified tumor cells
- For the stimulation of tumor‐specific cytolytic T lymphocytes the ESb tumor cells which are highly metastatic were infected with an avirulent strain of the paramyxovirus Newcastle Disease Virus
- Infection of ESb cells with low amounts of NDV was sufficient to lead to an increase in cytolytic activity of tumor‐specific CTL after sensitization in vivo and restimulation in vitro
- In split‐type experiments it could be shown at the clonal level that viral modification did not alter the specificity of ESb‐specific CTL
- NDV modification instead led to a selective augmentation of the TATA‐specific CTL response
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