(R) salsolinolN-methyltransferase activity increases in parkinsonian lymphocytes

An endogenous catechol isoquinoline, 1(R),2(N)-;6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, was proved to be a neurotoxin specific for dopamine neurons by in vivo and in vitro experiments

Makoto Naoi; Wakako Maruyama; Naoki Nakao; Tohru Ibi; Ko Sahashi; Margherita Strolin Benedetti

2005

Scholarcy highlights

  • An endogenous catechol isoquinoline, 1(R),2(N)-;6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, was proved to be a neurotoxin specific for dopamine neurons by in vivo and in vitro experiments
  • To clarify the mechanism of the increase, the activity of enzymes related to the metabolism of the neurotoxin was examined in lymphocytes prepared from parkinsonian patients and controls
  • The distribution of the activity was bimodal in the parkinsonian patients, whereas it was singular in controls
  • Increase of the neutral N-methyltransferase may be an endogenous factor in the pathogenesis of Parkinson's disease

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