Inorganic Nanomaterials as Promoters/Inhibitors of Amyloid Fibril Formation

This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns

Monika Holubov√°

2021

Scholarcy highlights

  • Inorganic nanoparticles that are biologically active and have a large specific surface area penetrate the human body and are able to persist in the environment and accumulate there
  • This review addresses the influence of inorganic nanoparticles on the process of amyloid fibril formation, which is a popular topic in nanoparticle science because of associated public health concerns
  • The effect of nanoparticles on amyloid fibril formation is dependent on several parameters such as nanoparticle size, shape, and surface chemistry
  • It was found that the same type of nanoparticle may have different effects on the process of amyloid fibril formation depending on the model system used
  • They can promote the fibrillation of some model protein systems, but, on the other hand, they can inhibit the fibrillation of others
  • Some nanoparticles can even decompose amyloid fibrils

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