- X-linked adrenoleukodystrophy
- spectroscopy
- Nuclear Magnetic Resonance
- Free Induction Decay
- N-Acetyl aspartate
- chemical shift
- magnetic resonance imaging
- magnetic resonance spectroscopy

We demonstrate the use of the model for the metabolite ratio for data obtained from twelve ALD patients and nine healthy subjects

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- Nuclear Magnetic Resonance was discovered independently by Felix Bloch and Edward Purcell in 1946
- There is an observable variation in orthogonality and standard deviation in the metabolite concentration estimates from the simulation and experiments done on the 3T Magnetic Resonance Imaging scanner for a 2DJ-PRESS sequence
- Focusing on the orthogonality of Glu and Gin spectra, simulation data of the 2DJ-PRESS sequence shows that the greatest orthogonality occurs around 55ms - 85ms
- Simulation of the 128-step Computer Tomography-PRESS sequence shows that the variation in orthogonality and standard deviation in metabolite estimates are more subtle and would improve at earlier tj steps
- To reduce the scan-time for the CT-PRESS experiment done on the 3T MRI scanner, an under-sampled 32-step CT-PRESS sequence was implemented and used
- The range of t1 steps for the 2D-JPRESS and CT-PRESS represents a possible subset of optimal t1 times for which the total scan-time can be shortened while maintaining quality of separation of Glu and Gin
- The range of t1 steps for the 2D-JPRESS and Computer Tomography-PRESS represents a possible subset of optimal t1 times for which the total scan-time can be shortened while maintaining quality of separation of Glu and Gin. In addition to evaluating orthogonality and standard deviation at each tl step for CTPRESS and 2D-JPRESS, the 1D spectra that result from averaging across TE's from the 2DJPRESS spectra, projecting the 2D CT-PRESS spectrum onto the fl axis, concatenating all available Free Induction Decay's from each t1 step, and the 1D spin echo at TE = 35ms were studied

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