Cytoskeleton Dynamics: Actin in Cell Invasion

Basement membrane is a dense sheet of specialised extracellular matrix that separates epithelial layers of cells from the underlying tissue

Rodrigo Cáceres; Julie Plastino

2017

Scholarcy highlights

  • Basement membrane is a dense sheet of specialised extracellular matrix that separates epithelial layers of cells from the underlying tissue
  • The exact cytoskeletal strategy that the cell uses to cross the physical BM barrier depends on the physiological context and the physical environment, as observed by examining actin structures in invading cancer and immune cells, and in cells that invade during developmental processes such as angiogenesis and anchor cell invasion in Caenorhabditis elegans
  • Shape changes and protrusions are necessary for cell invasion across basement membrane barriers
  • The actin dynamics strategy employed by an invading cell depends on the environment and the physiological context

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