Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors

FDA Approval and Regulation of Pharmaceuticals, 1983-2018 Global Burden of Cancer, 1990-2017 Global Burden of Skin Diseases, 1990-2017 Global Firearm Mortality, 1990-2016 Health Care Spending in the US and Other High-Income Countries Life Expectancy and Mortality Rates in the United States, 1959-2017 Medical Marketing in the United States, 1997-2016 Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter President Obama on US Health Care Reform The State of US Health, 1990-2016 US Burden of Cardiovascular Disease, 1990-2016 US Burden of Neurological Disease, 1990-2017 Waste in the US Health Care System: Estimated Costs and Potential for Savings

Debabrata Mukherjee

2003

Scholarcy highlights

  • FDA Approval and Regulation of Pharmaceuticals, 1983-2018 Global Burden of Cancer, 1990-2017 Global Burden of Skin Diseases, 1990-2017 Global Firearm Mortality, 1990-2016 Health Care Spending in the US and Other High-Income Countries Life Expectancy and Mortality Rates in the United States, 1959-2017 Medical Marketing in the United States, 1997-2016 Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter President Obama on US Health Care Reform The State of US Health, 1990-2016 US Burden of Cardiovascular Disease, 1990-2016 US Burden of Neurological Disease, 1990-2017 Waste in the US Health Care System: Estimated Costs and Potential for Savings
  • The results from Vioxx Gastrointestinal Outcomes Research Study showed that the relative risk of developing a confirmed adjudicated thrombotic cardiovascular event with rofecoxib treatment compared with naproxen was 2.38
  • There was no significant difference in cardiovascular event rates between celecoxib and nonsteroidal anti-inflammatory agents in Celecoxib Long-term Arthritis Safety Study
  • The available data raise a cautionary flag about the risk of cardiovascular events with COX-2 inhibitors
  • Further prospective trial evaluation may characterize and determine the magnitude of the risk

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