Naloxone-Reversible Analgesic Response to Combat-Related Stimuli in Posttraumatic Stress Disorder

We tested the hypothesis that exposure to a stimulus resembling the original traumatic event would induce naloxone-reversible analgesia in patients with posttraumatic stress disorder

Roger K. Pitman

2011

Scholarcy highlights

  • We tested the hypothesis that exposure to a stimulus resembling the original traumatic event would induce naloxone-reversible analgesia in patients with posttraumatic stress disorder
  • No decrease in pain ratings occurred in the subjects with PTSD in the naloxone condition
  • The subjects without PTSD did not show a decrease in pain ratings in either condition
  • The results are consistent with the induction of opioid-mediated stress-induced analgesia in the patients with PTSD
  • The results are consistent with the induction of opioid-mediated stress-induced analgesia in the patients with posttraumatic stress disorder

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