Amitriptyline hydrochloride was compared with placebo in 46 veterans with chronic posttraumatic stress disorder
2011
Key concepts
Scholarcy highlights
- Amitriptyline hydrochloride was compared with placebo in 46 veterans with chronic posttraumatic stress disorder
- In patients who completed 4 weeks, better outcome with amitriptyline was noted on the Hamilton depression scale only
- In the group completing 8 weeks of treatment, the drug was superior to placebo on Hamilton depression, Hamilton anxiety, Clinical Global Impression severity, and Impact of Event scales
- There was no evidence for drug effects on the structured interview for posttraumatic stress disorder
- At the end of treatment, 64% of the amitriptyline and 72% of the placebo samples still met diagnostic criteria for posttraumatic stress disorder
- Drug-placebo differences were greater in the presence of comorbidity in general, recovery rates were uniformly low in the presence of major depression, panic disorder, and alcoholism
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